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ChemInform Abstract: One-Pot Construction of Multiple Contiguous Chiral Centers Using Michael Addition of Chiral Amine.

✍ Scribed by Minoru Ozeki; Shunsuke Ochi; Noboru Hayama; Shinzo Hosoi; Tetsuya Kajimoto; Manabu Node

Publisher: John Wiley and Sons
Year: 2010
Weight: 66 KB
Volume: 41
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.201042024

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✦ Synopsis

Abstract

Tandem Michael—aldol, double Michael, and double Michael—aldol reactions with the chiral amine (I) allow efficient and stereoselective access to functionalized amines with up to five contiguous chiral centers in one pot.

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