## Abstract Tandem Michaelβaldol, double Michael, and double Michaelβaldol reactions with the chiral amine (I) allow efficient and stereoselective access to functionalized amines with up to five contiguous chiral centers in one pot.
ChemInform Abstract: Four Chiral Centers in a One-Pot Procedure. Analogues of Isosorbide.
β Scribed by Julio G. Urones; Isidro S. Marcos; Narciso M. Garrido; P. Basabe; Sonia G. San Feliciano; Raquel Coca; David Diez
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 27 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0931-7597
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β¦ Synopsis
Four Chiral Centers in a One-Pot Procedure. Analogues of Isosorbide.
-Lithiation of the previously reported diene (I) and following reaction with acetone leads to the diol (III) which can be directly cyclized to isosorbide analogue (IV) under Sharpless conditions. A racemic analogue can be obtained via the dihydrofuran (V). -(URONES, JULIO G.; MARCOS,
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