✍ Scribed by Thomas Billert; Rainer Beckert; Manfred Doering; Helmar Goerls
No coin nor oath required. For personal study only.
On the Chemistry of Pyrido[1,2-a]pyrazines -Reactivity Towards Heterocumulenes and Ketenes.
-New derivatizations and ring transformations of the title pyridopyrazine ring system are presented. Reaction of title compound (I) with isocyanates gives the acyl-aryl substituted pyridopyrazines (IV) via intermediate [2 + 2] cycloadducts (III). In the course of a hetero-metathesis, the new compounds (VI) are formed. The reaction of (I) with in situ generated ketenes gives pyrrolo-condensed pyridopyrazines (VIII) which can be further converted to pyridopyrrolinones (X). Acetyl chloride reacts with (I) to furnish exclusively the N-acylated product (XIId), whereas benzoyl chlorides give mixtures of N-monoacylated and diacylated products (XII) and (XIII), respectively.
-(BILLERT, THOMAS; BECKERT, RAINER;
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