A straightforward and efficient synthesis of the aldehyde (VIII), a known precursor of the halicholactones, is presented. The procedure is based on the asymmetric cyclopropanation of cinnamyl alcohol (I) according to Charette's protocol. -(MOHAPATRA, D.
ChemInform Abstract: Novel Palladium-Free Synthesis of a Key Quinazolinap Precursor.
β Scribed by Ludovic Milhau; Patrick J. Guiry
- Publisher
- John Wiley and Sons
- Year
- 2011
- Weight
- 30 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0931-7597
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A Novel Asymmetric Synthesis of 2-Azetidinones from Achiral Precursors. -Cyclocondensation of chloride (I) with p-methoxybenzylamine in the presence of stoichiometric amounts of a chiral salen-copper(II) is investigated. The desired azetidinone (III) is obtained with considerable enantioselectivity