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ChemInform Abstract: Novel Cytokine Release Inhibitors. Part 3. Truncated Analogues of Tripterine.

✍ Scribed by Wei He; Fu-Chih Huang; Ashvin Gavai; Wan K. Chan; George Amato; Kin-Tak Yu; Asher Zilberstein

Publisher
John Wiley and Sons
Year
2010
Weight
33 KB
Volume
30
Category
Article
ISSN
0931-7597

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✦ Synopsis

Novel Cytokine Release Inhibitors. Part 3. Truncated Analogues of Tripterine.

-Various truncated analogues of tripterine such as (XII), (XIII) and (XIV) are synthesized using the tricyclic and the tetracyclic intermediates (IX) and (VIII), resp., as the key substrates. It is clearly demonstrated that the small synthetic compounds have good cytokine release inhibitory effects, although less potent than tripterine. Moreover, it is established that the primary pharmacophore resides on the A/B rings. -(HE, WEI; HUANG,

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