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ChemInform Abstract: Novel AMPA Receptor Antagonists: Synthesis and Structure-Activity Relationships of 1-Hydroxy-7-(1H-imidazol-1-yl)-6-nitro-2,3(1H,4H) quinoxalinedione and Related Compounds.

✍ Scribed by J. OHMORI; M. SHIMIZU-SASAMATA; M. OKADA; S. SAKAMOTO

Publisher: John Wiley and Sons
Year: 2010
Weight: 35 KB
Volume: 28
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199704179

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✦ Synopsis

Novel AMPA Receptor Antagonists: Synthesis and Structure-Activity Relationships of 1-Hydroxy-7-(1H-imidazol-1-yl)-6-nitro-2,3(1H,4H) quinoxalinedione and Related Compounds.

-A series of title compounds, e.g. (VII), is prepared and evaluated for their affinity towards AMPA receptors. Derivative (VII) shows high affinity for the AMPA receptor with a Ki value of 0.021 µM, which is severalfold greater than that of YM90K (VIII) and NBQX (IX). -(OHMORI,

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