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ChemInform Abstract: New Synthetic Route to 10,11-Dihydro-5H-dibenzo(a,d)cyclohepten-5,10- imines Through Photoamination of 5-Alkoxy- and 5-Hydroxy-5H-dibenzo(a, d)cycloheptenes Followed by a Transannular Reaction with Acetic Acid.

โœ Scribed by M. YASUDA; T. WAKISAKA; R. KOJIMA; K. TANABE; K. SHIMA


Book ID
112028992
Publisher
John Wiley and Sons
Year
2010
Weight
33 KB
Volume
27
Category
Article
ISSN
0931-7597

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Bromine-Promoted Cyclization of an Olefinic ฮฑ-Aminonitrile: A Practical Synthesis of 5-Aminocarbonyl-10,11-dihydro-5H-dibenzo(a,d) cyclohepten-5,10-imine (ADCI). -ADCI (VII) is a selective, lowaffinity noncompetitive antagonist of the NMDA receptor showing promising anticonvulsant activity. In the