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ChemInform Abstract: Bromine-Promoted Cyclization of an Olefinic α-Aminonitrile: A Practical Synthesis of 5-Aminocarbonyl-10,11-dihydro-5H-dibenzo(a,d) cyclohepten-5,10-imine (ADCI).

✍ Scribed by J. GONZALEZ; F. I. CARROLL

Publisher: John Wiley and Sons
Year: 2010
Weight: 33 KB
Volume: 28
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199711122

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✦ Synopsis

Bromine-Promoted Cyclization of an Olefinic α-Aminonitrile: A Practical Synthesis of 5-Aminocarbonyl-10,11-dihydro-5H-dibenzo(a,d) cyclohepten-5,10-imine (ADCI).

-ADCI (VII) is a selective, lowaffinity noncompetitive antagonist of the NMDA receptor showing promising anticonvulsant activity. In the course of investigations related to (VII) an electrophile-promoted cyclization of the α-aminonitrile (IV), thus providing access to (VII), is discovered. -(GONZALEZ,

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