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ChemInform Abstract: New One-Pot Synthesis of a Chiral α-Hydroxy-γ-butyrolactone via Sequential Asymmetric Hydrogenation of an α,γ-Diketoester.

✍ Scribed by V. BLANDIN; J.-F. CARPENTIER; A. MORTREUX


Publisher
John Wiley and Sons
Year
2010
Weight
35 KB
Volume
30
Category
Article
ISSN
0931-7597

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## Abstract The reaction of the Reformatsky reagent derived from ethyl bromoacetate and subsequent coupling of the resulting Blaise intermediate with oxiranes allows the synthesis of the title compounds in fair yields.