ChemInform Abstract: New Methodology for the Synthesis of α,α-Dialkylamino Acids Using the “Self-Regeneration of Stereocenters” Method: α-Ethyl-α-phenylglycine.

✍ Scribed by M. J. O'DONNELL; Z. FANG; X. MA; J. C. HUFFMAN

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 32 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199817220

✦ Synopsis

New Methodology for the Synthesis of α,α-Dialkylamino Acids Using the "Self-Regeneration of Stereocenters" Method: α-Ethylα-phenylglycine.

-Chiral oxazolidines such as (III) derived from phenylglycine are alkylated with ethyl iodide (IV) with high diastereoselectivity. Following hydrolytic deprotection leads to optically active α-ethyl-αphenylglycine (VI). -(O'DONNELL, M.