ChemInform Abstract: New Cycloalkylpyrazoles as Potential Cyclooxygenase Inhibitors.

✍ Scribed by M. C. Cardia; L. Corda; A. M. Fadda; A. M. Maccioni; E. Maccioni; A. Plumitallo

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 29 KB
• Volume: 30
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199927143

✦ Synopsis

New Cycloalkylpyrazoles as Potential Cyclooxygenase Inhibitors.

-A series of new cycloalkylpyrazoles (VI) (15 examples) are synthesized based on the 1,3-dipolar cycloaddition reaction of nitrilimines (I) with enamine (II) in order to screen their capability to inhibit human cyclooxygenase.