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ChemInform Abstract: Monoaryl- and Bisaryldihydroxytropolones as Potent Inhibitors of Inositol Monophosphatase.

✍ Scribed by S. R. PIETTRE; et al. et al.

Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
29
Category
Article
ISSN
0931-7597

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✦ Synopsis

Monoaryl-and Bisaryldihydroxytropolones as Potent Inhibitors of Inositol Monophosphatase.

-An easy access to both series of title compounds as (VI) and (VIII) is possible in four steps by reversing the known synthetic reaction sequence, i.e. introducing to hydroxyl groups first and carrying out the Suzuki coupling reaction at the end. Both series (35 examples) are potent inhibitors of inositol monophosphatase. -(

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