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ChemInform Abstract: The 6-Hydroxy Group of Inositol 1-Phosphate Serves as an H-Bond Donor in Its Catalytic Hydrolysis by Inositol Monophosphatase: Design and Solid-Phase Synthesis of Mechanism Based Inhibitors

✍ Scribed by David Gani; Mahmoud Akhtar; Martin Beaton; David Miller; Roger Pybus; Duane Stones; Trevor Rutherford; John Wilkie

Publisher: John Wiley and Sons
Year: 2010
Weight: 27 KB
Volume: 32
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200151268

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Abstract

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The 6-OH Group of D-Inositol 1-Phosphate

The 6-OH Group of D-Inositol 1-Phosphate Serves as an H-Bond Donor in the Catalytic Hydrolysis of the Phosphate Ester by Inositol Monophosphatase

✍ David J. Miller; Martin W. Beaton; John Wilkie; David Gani 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 197 KB 👁 1 views

Inositol monophosphatase plays a pivotal role in the biosynthesis of secondary messengers and is believed to be a target for lithium therapy. It is established how a lithium ion works in inhibiting the enzyme but details of the mechanism for the direct magnesium ion activated hydrolysis of the subst