## Abstract ## Objective There is evidence that interleukinβ4 (ILβ4) plays a major role in the induction of extracellular matrix protein synthesis in fibrotic disease. We therefore examined the effect of ILβ4 on collagen synthesis in primary fibroblasts isolated from normal and TSK/+ mice, which s
β¦ LIBER β¦
ChemInform Abstract: Molecular Mechanisms of Regulation of Type I Collagen Biosynthesis
β Scribed by Qingjian Wang; Rajendra Raghow
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 24 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0931-7597
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## Abstract Composition of extracellular matrix (ECM) is crucial to the establishment and maintenance of epithelial apicalβbasolateral polarity. Increased ECM rigidity caused by deposition of fibrillar collagen, for example, collagen type I (Colβ1), promotes loss of epithelial polarity and tumor pr