ChemInform Abstract: Microwave Synthesis of 9-Substituted Acridine Derivatives.
β Scribed by Eva Veverkova; Marika Noskova; Stefan Toma
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 26 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0931-7597
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Reduction of 9-Substituted Acridines with Nickel-Aluminum Alloy. -Octahydroacridines (IV) and dihydroacridines (II) are obtained as major products by treatment of acridines (I) with Ni-Al alloy in acidic solution. The yields strongly depend upon the C-9 substituent and the pH of the reaction medium
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A Versatile Synthesis of Acridine-1,9-diones. -Michael addition of alkenes to 2-ethoxycarbonylmethylquinolin-4-one (I) and subsequent PPA-induced cyclization of the thus obtained C-Ξ±-alkylated products (cf. (III), (VI)) provides a new and general route to acridine-1,9-diones (cf. (IV), (VII); 6 exa