ChemInform Abstract: Lost in Transcription — Inhibition of RNA Polymerase
✍ Scribed by Dieter Haebich; Franz von Nussbaum
- Publisher
- John Wiley and Sons
- Year
- 2009
- Weight
- 11 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0931-7597
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract ## Background RNA polymerase III (pol III)‐dependent transcripts are involved in many fundamental activities in a cell, such as splicing and protein synthesis. They also regulate cell growth and influence tumor formation. During recent years vector‐based systems for expression of short
S. typhimurium strain BY324 is temperature sensitive due to a mutation (rpo C32) in the gene for the RNA polymerase fi' subunit. Transcription of T7 DNA by RNA polymerase purified from this strain is temperature sensitive in vitro. The enzyme is slightly defective in template binding and RNA chain i
Coumermycin A1, a specific inhibitor of DNA gyrase, differentially changes the spectrum of proteins synthesized in wild type E. coli cells but has no effect on the protein spectrum in mutant cells with coumermycin-resistant DNA gyrase. The rpoB265 mutation affecting RNA polymerase decreases the coum