ChemInform Abstract: Lipase-Catalyzed Preparation of Optically Active γ-Substituted- methyl-γ-butyrolactones.
✍ Scribed by H.-J. HA; D.-G. YI; K.-N. YOON; C. E. SONG
- Book ID
- 112040028
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 28 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0931-7597
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## Abstract Both enantiomers of the six major kinds of __γ__‐lactones were synthesized to >98% e.e. in four steps, starting from succinic anhydride. The key features were the syntheses of the various __rac__‐__N__‐methyl‐4‐hydroxyalkanamides via Grignard reaction and the enantioselective acetylatio
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