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ChemInform Abstract: KNI-272, a Highly Selective and Potent Peptidic HIV Protease Inhibitor

โœ Scribed by Mitsunobu Doi; Toshimasa Ishida; Yoshio Katsuya; Masahiro Sasaki; Taizo Taniguchi; Hiroshi Hasegawa; Tsutomu Mimoto; Yoshiaki Kiso


Publisher
John Wiley and Sons
Year
2010
Weight
29 KB
Volume
33
Category
Article
ISSN
0931-7597

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The effects of dose on the pharmacokinetic characteristics of KNI-272 were evaluated in rats after intravenous (iv) administration. The plasma kinetics of KNI-272 were dose-independent within a dose range of 1.0 to 10.0 mg/kg. However, when the dose was increased to 50.0 mg/kg, the area under the pl

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KNI-272 is a tripeptide drug that has a strong pharmacological potential for treating human immunodeficiency virus type 1 (HIV-1). We have already reported the pharmacokinetic characteristics of KNI-272 after intravenous and intraduodenal (ID) administrations to rats. In this study, KNI-272 was admi