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ChemInform Abstract: Ionotropic Excitatory Amino Acid Receptor Ligands. Synthesis and Pharmacology of a New Amino Acid AMPA Antagonist.

✍ Scribed by Ulf Madsen; Frank A. Sloek; Tine B. Stensboel; Hans Braeuner-Osborne; Hans-Christian H. Luetzhoeft; Miguel V. Poulsen; Lisbeth Eriksen; Povl Krogsgaard-Larsen

Publisher
John Wiley and Sons
Year
2010
Weight
29 KB
Volume
31
Category
Article
ISSN
0931-7597

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✦ Synopsis

Abstract

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable via the β€œReferences” option.

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We have previously shown that (RS)-2-amino-2-(5-tert-butyl-3-hydroxyisoxazol-4-yl)acetic acid (ATAA) is an antagonist at N-methyl-D-aspartic acid (NMDA) and (RS)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) receptors. We have now resolved ATAA via diastereomeric salt formation us