Dipeptidyl and tripeptidyl heterocycles designed to mimic peptide ketoamides and ketoacids were prepared and evaluated in vitro as inhibitors of human calpain I. Boc-Leu-Leu-imidazole (12) inhibited calpain I at low micromolar concentrations.
β¦ LIBER β¦
ChemInform Abstract: Inhibition of Calpain by Peptidyl Heterocycles.
β Scribed by M. TAO; R. BIHOVSKY; J. C. KAUER
- Book ID
- 101841726
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 28 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0931-7597
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