The Use of Zinc Enolates in the Synthesis of a Key Intermediate for the Preparation of Trinem Antibiotics. -The reaction of the azetidinone (I) with zinc enolates derived from a chiral methoxycyclohexanone provides the trinem antibiotic key intermediate (III) with good diastereoselectivity. -(KENNE
ChemInform Abstract: In situ Activated Zinc—Copper Couple for the Preparation of a Key Intermediate in the Synthesis of Dideoxyinosine (DDI).
✍ Scribed by J. L. DILLON
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 28 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
In situ Activated Zinc-Copper Couple for the Preparation of a Key Intermediate in the Synthesis of Dideoxyinosine (DDI).
-Compound (III) is prepared as a key intermediate for the synthesis of the AIDs drug dideoxyinosine. The reaction can be used for the large-scale synthesis of (III). -(DILLON,
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