ChemInform Abstract: Improved Scalable Syntheses of Mono- and Bisurethane Derivatives of Ornithine.
β Scribed by Stanislaw Wiejak; Elzbieta Masiukiewicz; Barbara Rzeszotarska
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 26 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0931-7597
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New Efficient Syntheses of Ξ±-Difluoromethyl-and Ξ±-Trifluoromethylornithine. -Ornithines (V), possessing a broad spectrum of biological activities including anticancer activity, are prepared in three steps. The key step is the regioselective alkylation of the imine (I) with the acetylide (II) in exc