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ChemInform Abstract: Highly Stereoselective trans Addition of π-Type Nucleophiles to a Bicyclic N-Acyliminium Ion — Application to the Synthesis of Indolizidine and Pyrrolizidine Alkaloids.

✍ Scribed by H. DHIMANE; C. VANUCCI-BACQUE; L. HAMON; G. LHOMMET


Publisher
John Wiley and Sons
Year
2010
Weight
35 KB
Volume
30
Category
Article
ISSN
0931-7597

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Highly Stereoselective trans Addition of
✍ Hamid Dhimane; Corinne Vanucci-Bacqué; Louis Hamon; Gérard Lhommet 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 446 KB

Enantiopure bicyclic 5-ethoxytetrahydropyrrolo[1,2-c]oxa-disubstituted pyrrolidines was illustrated by formal syntheses of 3,5-disubstituted indolizidine toxins, starting from 5-zol-3-one 1b was prepared in two steps from the known tosylate 4, which is readily available from (S)-pyroglutamic allylte