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ChemInform Abstract: Highly Stereoselective Hydrogenations as Key Steps in the Total Synthesis of Statins

✍ Scribed by Natalia Andrushko; Vasyl Andrushko; Vitali Tararov; Andrei Korostylev; Gerd Koenig; Armin Boerner

Publisher
John Wiley and Sons
Year
2010
Weight
15 KB
Volume
41
Category
Article
ISSN
0931-7597

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Highly stereoselective hydrogenations—As
Highly stereoselective hydrogenations—As key-steps in the total synthesis of statins
✍ Natalia Andrushko; Vasyl Andrushko; Vitali Tararov; Andrei Korostylev; Gerd Köni 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 202 KB 👁 1 views

## Abstract Statins are inhibitors of 3‐hydroxy‐3‐methyl‐glutaryl coenzyme A reductase (HMG‐CoA reductase) and became the standard of care for treatment of hypercholesterolemia because of their efficacy, safety, and long‐term benefits. They are administered as diastereo‐ and enantiomerically pure c