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ChemInform Abstract: Highly Enantioselective Organocatalytic Michael Addition of Nitroalkanes to 4-Oxo-enoates.

✍ Scribed by Hai-Hua Lu; Xu-Fan Wang; Chang-Jiang Yao; Jian-Ming Zhang; Hong Wu; Wen-Jing Xiao


Publisher
John Wiley and Sons
Year
2009
Weight
46 KB
Volume
40
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

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## Abstract An organocatalytic enantioselective Michael addition of 2‐hydroxy‐1,4‐naphthoquinone to β,γ‐unsaturated α‐oxo esters has been developed. The process was promoted by bifunctional chiral amine derived squaramides according to a hydrogen‐bonding mediated activation mechanism and afforded t