ChemInform Abstract: Highly Diastereo- and Enantioselective Organocatalytic Michael Addition of α-Ketoamides to Nitroalkenes.
✍ Scribed by Olivier Basle; Wilfried Raimondi; Maria del Mar Sanchez Duque; Damien Bonne; Thierry Constantieux; Jean Rodriguez
- Publisher
- John Wiley and Sons
- Year
- 2011
- Weight
- 33 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0931-7597
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## Abstract A variety of enantioenriched β‐nitrophosphonates (III) is readily obtained by asymmetric Michael addition of diphenylphosphite (II) to nitroolefins (I) in the presence of a bifunctional amine—thiourea organocatalyst.
## Diastereo-and Enantioselective Synthesis of Vicinal Diamines via Aza-Michael Addition to Nitroalkenes. -Key step in the diastereoand enantioselective synthesis of vicinal diamines is an auxiliary-controlled diastereoselective conjugate addition of a chiral ammonia equivalent (II) to nitroalken