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ChemInform Abstract: Highly Efficient Synthesis of 2(S)-3(R,S)-2-Amino-4,4-difluoro-1,6- diphenyl-3-hydroxyhexane - The Key Intermediate for a Series of Potent HIV Proteinase Inhibitors.

โœ Scribed by H. L. SHAM; D. A. BETEBENNER; N. E. WIDEBURG; D. J. KEMPF; J. J. PLATTNER; D. W. NORBECK


Book ID
112024489
Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
26
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Synthetic Studies o
โœ T. MURAKAMI; T. SHIMIZU ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 35 KB ๐Ÿ‘ 1 views

Synthetic Studies on Sphingolipids. Part 4. Improved Synthesis of (4S)-4-[(1S,2R)-1,2-Epoxybut-3-enyl]-2-phenyl-2-oxazoline, a Key Intermediate for Sphingolipids. -A novel route to the title compound (VIII) is reported with an oxidative bromination [(VI) โ†’ (VII)] as the key step.