ChemInform Abstract: A Diastereoselective Synthesis of (2S,3R,4S)-2-Amino-1-cyclohexyl-6- methylheptane-3,4-diol, the Abbott Aminodiol.
β Scribed by C. W. ALEXANDER; D. C. LIOTTA
- Book ID
- 112034082
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 30 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0931-7597
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The N-Boc dihydroxyethylene dipeptide isostere 7 and its N-Boc 3-(thiazol-4-ylJalany1 derivative 8 were synthesized, without purification of intermediates, from (4S~R)-22-dimethyl-4-(2-methy~propylJ-5-hydro~~thyl-l.3-dioxolane (361, in 24 and 32% overall yield, respectively, Alcohol 38 was readily p
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