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ChemInform Abstract: Highly Diastereo- and Enantioselective Synthesis of syn-β-Substituted Tryptophans via Asymmetric Michael Addition of a Chiral Equivalent of Nucleophilic Glycine and Sulfonylindoles.

✍ Scribed by Jiang Wang; Shengbin Zhou; Daizong Lin; Xiao Ding; Hualiang Jiang; Hong Liu

Publisher: John Wiley and Sons
Year: 2011
Weight: 50 KB
Volume: 42
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.201147191

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✦ Synopsis

Abstract

The asymmetric Michael addition of a chiral Ni(II) complex of a Schiff base of glycine (I) with a broad range of sulfonylindoles offers a simple and mild protocol for the preparation of syn‐configured β‐substituted tryptophans.

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