ChemInform Abstract: Highly Active Potential Antituberculotics: 3-(4-Alkylphenyl)-4-thioxo-2H-1,3-benzoxazine-2(3H)-ones and 3-(4-Alkylphenyl)-2H-1,3-benzoxazine-2,4(3H)-dithiones Substituted in Ring-B by Halogen.
✍ Scribed by Karel Waisser; Josef Matyk; Jiri Kunes; Rafael Dolezal; Jarmila Kaustova; Hans-Martin Dahse
- Publisher
- John Wiley and Sons
- Year
- 2009
- Weight
- 18 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0931-7597
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## Abstract Substituted 2‐(benzylamino)‐2__H__‐1,4‐benzoxazin‐3(4__H__)‐ones are unstable under alkaline and acidic conditions, undergoing opening of the benzoxazinone ring. 2‐Bromo‐2__H__‐1,4‐benzoxazin‐3(4__H__)‐ones show similar degradation under alkaline conditions, while replacement of Br at C