A new approach to the synthesis of 2-R-5-benzyl-2-thiazolines with the use of chloro-and bromoarylation products of allyl isothiocyanate with arenediazonium halides was elaborated. The isothiocyanates obtained were reacted with ammonia, aliphatic or aromatic amines, and sodium methoxide. The use of
ChemInform Abstract: Halogenoarylation of Allyl Isothiocyanate: Synthesis of 2,5-Disubstituted 2-Thiazolines.
β Scribed by Mykola D. Obushak; Volodymyr V. Karpyak; Mykola I. Ganushchak
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 33 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0931-7597
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Preparation of 2,5-Disubstituted 2-Thiazolines. -A new synthetic access to the title thiazolines is presented. The isothiocyanates (I) and (VI), prepared by chloroarylation of allylisothiocyanate with aryldiazonium chlorides, undergo cyclization in the presence of bases to afford the target thiazol
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