Treatment of organolithiums, Grignard reagents, or enolates with N-methoxy-N-methylformamide leads to formylated products in good yields without competing secondary processes.
ChemInform Abstract: Formylations of Anions with a “Weinreb” Formamide: N-Methoxy-N-methylformamide.
✍ Scribed by Bruce H. Lipshutz; Steven S. Pfeiffer; Will Chrisman
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 28 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Abstract
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1998 carboxylic amides carboxylic amides (acyclic compounds) P 0320 ## 42 -076 A New Synthesis of α,β-Unsaturated N-Methoxy-N-methylamides. -A new method to synthesize Weinreb-amides of type (III) by homologation of alkylhalides is reported. Sulfoxide (I) is synthesized in two steps with an overa