ChemInform Abstract: First Total Synthesis of (+)-Caparratriene.

✍ Scribed by J. LI; Z. LIU; J. LAN; Y. LI

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 28 KB
• Volume: 28
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199733249

✦ Synopsis

First Total Synthesis of (+)-Caparratriene.

-The title compound (V), a new sesquiterpene hydrocarbon with significant growth-inhibitory activity against CEM leukemia cells, is synthesized from commercially available citronellal (I) via three steps in an overall yield of 18%. Coupling reagent (II) is conveniently prepared from 3-methyl-2-buten-1-ol in two steps. -(LI, J.;