First Synthesis of Medium-Sized Ring All
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Moritz Perscheid; Dieter Schollmeyer; Udo Nubbemeyer
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Article
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2011
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John Wiley and Sons
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English
β 129 KB
## Abstract Mediumβsized lactams bearing an axially chiral allene unit have been synthesized by using an azaβketene Claisen rearrangement. Starting from 2βalkynylpiperidines or 2βalkynylazepines, ring enlargement enabled the highly diastereoselective formation of 10β or 11βmembered lactams with a 4