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ChemInform Abstract: First Synthesis of Medium-Sized Ring Allenyl Lactams.

✍ Scribed by Moritz Perscheid; Dieter Schollmeyer; Udo Nubbemeyer


Publisher
John Wiley and Sons
Year
2012
Weight
24 KB
Volume
43
Category
Article
ISSN
0931-7597

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First Synthesis of Medium-Sized Ring All
✍ Moritz Perscheid; Dieter Schollmeyer; Udo Nubbemeyer πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 129 KB

## Abstract Medium‐sized lactams bearing an axially chiral allene unit have been synthesized by using an aza‐ketene Claisen rearrangement. Starting from 2‐alkynylpiperidines or 2‐alkynylazepines, ring enlargement enabled the highly diastereoselective formation of 10‐ or 11‐membered lactams with a 4