Trifluoromethylated phosphines R,PCF, ( R = N E t , Me, IPr) were methylated by CH,OSO,CF, yielding the corresponding phosphonium salts [R,P(CF,)CHJ+ [F,CSOJ-. Treatment with LiN(SiMe,), at -80Β°C furnished the phosphorus ylides R,P(CF
ChemInform Abstract: First P-Trifluoromethylated Ylides.
β Scribed by U. DIECKBREDER; E. LORK; G.-V. ROESCHENTHALER; A. A. KOLOMEITSEV
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 27 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0931-7597
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β¦ Synopsis
First P-Trifluoromethylated Ylides.
-Synthesis and trapping of P-trifluoromethylated phosphorus ylides (IV) is reported for the first time. -
π SIMILAR VOLUMES
Bis(trifluoromethyl) phosphines RP-(CF 3 ) 2 (R = Me, NEt 2 ) were methylated by MeOSO 2 -CF 3 , yielding the respective phosphonium salts [RP(CF 3 ) 2 Me] + and CF 3 SO 3 -. Deprotonation using MeN P(NEt 2 ) 3 led to the phosphorus ylides RP-(CF 3 ) 2 CH 2 , stable in solution at ambient temperatu
First Synthesis of ortho-Trifluoromethylated Aryl Triflates. -A very useful approach is used for the preparation of the title triflates, e.g. (IV), (VI) and (XI). This efficient methodology is applied in the synthesis of the retinoid derivative (XIII). -(QUING, F.
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