ChemInform Abstract: First Functionalization by Metallation of the Benzene Moiety of Quinazolines. Diazines. Part 19.

✍ Scribed by N. PLE; A. TURCK; V. CHAPOULAUD; G. QUEGUINER

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 35 KB
• Volume: 28
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199726186

✦ Synopsis

First Functionalization by Metallation of the Benzene Moiety of Quinazolines. Diazines. Part 19.

-4-Substituted quinazolines are found to undergo unexpected regioselective lithiation at C-8. This offers an efficient pathway to a large number of new substituted quinazolines which cannot be easily prepared by other routes. All attempts to functionalize the 5 position are unsuccessful. An unexpected chlorine-lithium exchange is observed in the case of the quinazoline (XV). -(PLE, N.; TURCK, A.;