ChemInform Abstract: Facile Synthesis of Pyrazoles and Pyrroles via Thermolysis of Tetrazolo[1,5-b]pyridazines, Tetrazolo[1,5-a]pyrimidines and Tetrazolo[1,5-a]pyridines.
β Scribed by Daniele Simoni; Riccardo Rondanin; Giancarlo Furno; Enrico Aiello; Francesco Paolo Invidiata
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 28 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0931-7597
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## Abstract Several 5βalkoxyβtetrazolo[1,5β__a__]quinazoline derivatives have been synthesized by reacting 2,4βdichloroquinazoline with various phenols or aliphatic alcohol and then with sodium azide. The structures of these compounds have been confirmed by IR, MS, ^1^HβNMR, and elementary analysis
1H, 13C and 15N NMR data are reported for nine tetrazoles. Five of these compounds are found to exhibit valence tautomeric equilibrium between the tetrazole and azide forms. The position of this equilibrium at 298 K is found to be dependent on the solvent and the position and nature of the substitue