ChemInform Abstract: Facile Synthesis of 1-Aryl-2,3-dihydro-1H-isoindoles by Cyclization of N-Formyliminium Ion via Geometrically Disfavored 5-endo-Trig Process.
β Scribed by Michikazu Kitabatake; Toshiaki Saitoh; Takehiro Sano; Yoshie Horiguchi
- Publisher
- John Wiley and Sons
- Year
- 2009
- Weight
- 26 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0931-7597
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β¦ Synopsis
Abstract
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Stereocontrolled Synthesis of 5-Acyl-3,4-dihydro-2H-pyrroles and Related Heterocycles via Intramolecular 2-Propylidene-1,3-bis(silane)-Acylnitrilium Ion Cyclizations. -The title reaction is found to proceed with good to excellent diastereoselectivity. Reduction of prepared Ξ΄1-pyrrolines results in s