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ChemInform Abstract: Enzyme-Catalyzed Reactions. Part 19. Enzyme Catalyzed Addition of Hydrocyanic Acid to Substituted Pivalaldehydes - A Novel Synthesis of ( R)-Pantolactone.

✍ Scribed by F. EFFENBERGER; J. EICHHORN; J. ROOS


Book ID
112023182
Publisher
John Wiley and Sons
Year
2010
Weight
29 KB
Volume
26
Category
Article
ISSN
0931-7597

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Enzyme catalyzed addition of hydrocyanic
✍ Franz Effenberger; Joachim Eichhorn; JΓΌrgen Roos πŸ“‚ Article πŸ“… 1995 πŸ› Elsevier Science 🌐 English βš– 608 KB

R)-Cyanohydrins (R)-2b-h are obtained in good optical yields by (R)-oxynitrilase catalyzed enantioselective addition of HCN to [~-substituted pivalaldehydes lb-h. Under optimized reaction conditions with highly purified (R)-oxynitrilase, hydroxypivalaldehyde (la) is converted to (R)-2a in satisfacto