ChemInform Abstract: Enzymatic Preparati
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R. CHENEVERT; G. COURCHESNE
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Article
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2010
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John Wiley and Sons
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Enzymatic Preparation of an Optically Active Precursor of the CC-1065/ Duocarmycin Pharmacophore. -Both enantiomers of the monoacetate (III) are synthesized via enzymatic desymmetrization of propanediol (I). Incorporation of these optically active monoacetates into the established synthetic routes