ChemInform Abstract: Enantiospecific Synthesis of Analogues of the Diketide Intermediate of the Erythromycin Polyketide Synthase (PKS).
โ Scribed by Rebecca C. Harris; Annabel L. Cutter; Kira J. Weissman; Ulf Hanefeld; Maire C. Timoney; James Staunton
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 29 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0931-7597
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The production of genetically engineered polyketides depends critically on thioesterase activity for product release. In vitro studies with the thioesterase from the erythromycin polyketide synthase (PKS) have demonstrated that the ability of this enzyme to act as a universal decoupler is limited, b
Monocerin (5) is a polyketide fungal metabolite that exhibits antifungal, insecticidal, and plant pathogenic properties. It has been isolated from several fungal species, including Dreschlera monoceras, [1] D. ravenelii, [2] Exserohilum turcum, [3] and, along with the related fusarentin ethers, for