ChemInform Abstract: Enantioselective α-Arylation of Aldehydes via the Productive Merger of Iodonium Salts and Organocatalysis.
✍ Scribed by Anna E. Allen; David W. C. MacMillan
- Publisher
- John Wiley and Sons
- Year
- 2011
- Weight
- 42 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0931-7597
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📜 SIMILAR VOLUMES
## Abstract The first enantioselective α‐benzylation of aldehydes with electron‐deficient aryl and heteroaryl substrates proceeds in the presence of a chiral imidazolidinone organocatalyst, an iridium photoredox catalyst, and in the presence of household fluorescent light.
The enantioselective introduction of electrophiles a to carbonyl groups is a central topic in asymmetric synthesis. Although asymmetric a-alkylations have been well developed, high enantioselectivity in a-arylation of ketones has only been achieved in a very limited number of cases. These involve ar