ChemInform Abstract: Enantioselective Total Synthesis of Epothilone A Using Multifunctional Asymmetric Catalyses.
β Scribed by Daisuke Sawada; Masakatsu Shibasaki
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 32 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0931-7597
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This study was financially supported by CREST. We thank Dr. Motomu Kanai, Yoshitaka Hamashima, and Rie Namme for their support and fruitful discussion.
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Total Synthesis of (-)-Epothilone A. -A key step in the synthesis of the title antitumor natural product is the highly stereoselective aldol reaction of the optically active building blocks (I) and (II). Esterification of the product (IV) with the subunit (V) leads to the stereochemically homogeneou