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ChemInform Abstract: Enantioselective Synthesis of Trifluoromethyl-Substituted 2-Isoxazolines: Asymmetric Hydroxylamine/Enone Cascade Reaction.

✍ Scribed by Kazutaka Matoba; Hiroyuki Kawai; Tatsuya Furukawa; Akihiro Kusuda; Etsuko Tokunaga; Shuichi Nakamura; Motoo Shiro; Norio Shibata

Publisher
John Wiley and Sons
Year
2010
Weight
43 KB
Volume
41
Category
Article
ISSN
0931-7597

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✦ Synopsis

Abstract

The title reaction consists of an addition/cyclization/dehydration sequence and affords the biologically important chiral 3,5‐diaryl‐5‐(trifluoromethyl)‐2‐isoxazolines in excellent yields with high e.e.

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## Abstract A quinine‐derived thiourea is the best catalyst for the conjugate addition of trifluoromethyl substituted nucleophiles to β,γ‐unsaturated α‐keto esters.