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ChemInform Abstract: Asymmetric Synthesis of Trifluoromethyl Substituted Dihydropyrans via Organocatalytic Cascade Michael—Hemiketalization Reaction.

✍ Scribed by Jin-jia Wang; Zhi-peng Hu; Chun-liang Lou; Jun-liang Liu; Xue-ming Li; Ming Yan

Publisher
John Wiley and Sons
Year
2011
Weight
38 KB
Volume
42
Category
Article
ISSN
0931-7597

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✦ Synopsis

Abstract

A quinine‐derived thiourea is the best catalyst for the conjugate addition of trifluoromethyl substituted nucleophiles to β,γ‐unsaturated α‐keto esters.

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ChemInform Abstract: Enantioselective Sy
ChemInform Abstract: Enantioselective Synthesis of Trifluoromethyl-Substituted 2-Isoxazolines: Asymmetric Hydroxylamine/Enone Cascade Reaction.
✍ Kazutaka Matoba; Hiroyuki Kawai; Tatsuya Furukawa; Akihiro Kusuda; Etsuko Tokuna 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 43 KB

## Abstract The title reaction consists of an addition/cyclization/dehydration sequence and affords the biologically important chiral 3,5‐diaryl‐5‐(trifluoromethyl)‐2‐isoxazolines in excellent yields with high e.e.