ChemInform Abstract: Enantioselective Synthesis of Phenylpropanetriols.
β Scribed by M. DELLAGRECA; A. FIORENTINO; P. MONACO; L. PREVITERA
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 37 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0931-7597
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β¦ Synopsis
Enantioselective Synthesis of Phenylpropanetriols. -The enantioselective synthesis of D-threo-1-(4-hydroxy-3-methoxyphenyl)-1,2,3-propanetriol, an aquatic plant metabolite, and its three stereoisomers [cf. (VII), (XII)] from ferulic acid (I) involving a Sharpless asymmetric dihydroxylation key step is carried out in order to obtain data on stereostructure-bioactivity relationships.
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Enantioselective Synthesis of Ξ³-Hydroxynorvaline. -Key step in the synthesis of title compound (VI) is the diastereoselective alkylation of chiral Schiff base (I) with iodide ( II) obtained by ring opening of (S)-propylene oxide using Tms-I at low temperatures. -(JACOB, M.; ROUMESTANT,