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ChemInform Abstract: Efficient Synthesis of Ethyl 3-Alkyl-4-oxo-2-thioxo-1,3-thiazolane-5-carboxylates from the Reaction of Carbon Disulfide and Primary Amines in the Presence of Diethyl 2-Chloromalonate.

✍ Scribed by Issa Yavari; Rahimeh Hajinasiri; S. Zahra Sayyed-Alangi; Nasir Iravani


Publisher
John Wiley and Sons
Year
2008
Weight
30 KB
Volume
39
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

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Synthesis and Exchange Reactions of 5-Alkyl-2-oxo-6-thioxo-1,2,3,6-Tetrahydropyrimidine-4-carboxylic Acids. -The title compounds are prepared as potential dihydroorotase inhibitors. H/D-exchange studies establish a high tendency towards epimerization at C-5. No epimerization is observed under physi