ChemInform Abstract: Efficient and Divergent Synthesis of Fully Substituted 1H-Pyrazoles and Isoxazoles from Cyclopropyl Oximes.
โ Scribed by Kewei Wang; Dexuan Xiang; Jinying Liu; Wei Pan; Dewen Dong
- Publisher
- John Wiley and Sons
- Year
- 2008
- Weight
- 29 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0931-7597
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โฆ Synopsis
Abstract
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๐ SIMILAR VOLUMES
## Abstract Starting from known ฮฑ,ฮฑโdioxoketen dithioacetals (I) some new pyrazoles and isoxazoles are synthesized by an ecofriendly procedure.
## Abstract Reaction of spirocyclopropanepyrazole derivative (I) with ฮฑโchloro esters (III) in the presence of a NaI/K~2~CO~3~ system results in cyclopropane ring opening and subsequent Cโ or Nโsubstitution to furnish dihydropyridazines (IV) and Nโsubstituted dihydropyrazoles (V).