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ChemInform Abstract: Efficient Acylation of Hydroxy Functions by Means of Fmoc Amino Acid Fluorides.

✍ Scribed by D. GRANITZA; M. BEYERMANN; H. WENSCHUH; H. HABER; L. A. CARPINO; G. A. TRURAN; M. BIENERT

Book ID
112029052
Publisher
John Wiley and Sons
Year
2010
Weight
23 KB
Volume
27
Category
Article
ISSN
0931-7597

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✍ Jeremy Green; Kimberly Bradley πŸ“‚ Article πŸ“… 1993 πŸ› Elsevier Science 🌐 French βš– 382 KB

The data presented suggests that esteritication of hydroxy-functionalized resins with Fmoc-protected amino acids proceeds best in low polarity solvents such as CH2C12 and THF and that pytidine, as co-solvent, is a suitable acylatiou catalyst. This has teen demonstrated using DIUHOBt activation, as w