✦ LIBER ✦
Studies on the acylation of hydroxy-functionalized resins using Fmoc amino acids activated using diisopropylcarbodiimide/HOBt or as acid fluorides
✍ Scribed by Jeremy Green; Kimberly Bradley
- Book ID
- 104203477
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- French
- Weight
- 382 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0040-4020
No coin nor oath required. For personal study only.
✦ Synopsis
The data presented suggests that esteritication of hydroxy-functionalized resins with Fmoc-protected amino acids proceeds best in low polarity solvents such as CH2C12 and THF and that pytidine, as co-solvent, is a suitable acylatiou catalyst. This has teen demonstrated using DIUHOBt activation, as well as Fmoc-protected amino acid fluorides which are excellent reagents for rapid, racemization-free acylation of hydroxy-functionalixed resins used in solid phase peptide synthesis.